Gene Targeting | DATOSPDF

Genetic unmasking of epigenetically silenced tumor suppressor genes in colon cancer cells deficient in DNA methyltransferases

Genetics / Epigenetics / Transcription Factors / Gene Silencing / Colorectal cancer / Biological Sciences / DNA / Cell line / Humans / Female / Calcium channels / Nucleic acid hybridization / Male / Human Molecular Genetics / DNA methylation / CpG islands / Calcium Channel / Tumor Suppressor Gene / Colon cancer / Gene Targeting / Epigenetica / CpG island / Biological Sciences / DNA / Cell line / Humans / Female / Calcium channels / Nucleic acid hybridization / Male / Human Molecular Genetics / DNA methylation / CpG islands / Calcium Channel / Tumor Suppressor Gene / Colon cancer / Gene Targeting / Epigenetica / CpG island

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Dopaminergic Supersensitivity in G Protein-Coupled Receptor Kinase 6Deficient Mice

Cognitive Science / Animal Behavior / Dopamine / Mice / Animals / Cocaine / Amphetamine / dopamine receptor D4 / Neurons / Neuron / Gene Targeting / G protein / Neurosciences / Motor activity / Corpus striatum / Cocaine / Amphetamine / dopamine receptor D4 / Neurons / Neuron / Gene Targeting / G protein / Neurosciences / Motor activity / Corpus striatum

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Efficient sequential repetitive gene deletions in Neurospora crassa employing a self-excising β-recombinase/six cassette

Microbiology / Molecular Biology / Medical Microbiology / Neurospora crassa / Genetics & Microbial Biotechnology / Gene Targeting

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Prostate targeting: PSP94 gene promoter/enhancer region directed prostate tissue-specific expression in a transgenic mouse prostate cancer model

Clinical Trial / Gene Therapy / Immunohistochemistry / Prostate Cancer / Cell Culture / Transgenic Mice / Biological Sciences / Mice / Animals / Male / Gene Targeting / Disease Progression / Amino Acid Profile / Transgenic Mouse Technology / Tumor Progression / Tissue Specificity / Transgenic Mice / Biological Sciences / Mice / Animals / Male / Gene Targeting / Disease Progression / Amino Acid Profile / Transgenic Mouse Technology / Tumor Progression / Tissue Specificity

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Cbl-3-Deficient Mice Exhibit Normal Epithelial Development

Cellular Biology / In Situ Hybridization / Biological Sciences / Molecular and cellular biology / Humans / Keratinocytes / Mice / Animals / Epidermal Growth Factor / Epithelium / Epithelial cells / Ubiquitin ligase / Gene Targeting / Gastrointestinal Tract / Reproductive System / Gene Expression Regulation / Tyrosine Kinase / Keratinocytes / Mice / Animals / Epidermal Growth Factor / Epithelium / Epithelial cells / Ubiquitin ligase / Gene Targeting / Gastrointestinal Tract / Reproductive System / Gene Expression Regulation / Tyrosine Kinase

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Vascular Endothelial Growth Factor-B-Deficient Mice Display an Atrial Conduction Defect

Physiology / Conduction / Fertility / Gene expression / Electrocardiography / Mice / Female / Animals / Male / Heart / Fibroblast Growth Factor / Phenotype / Clinical Sciences / Eye / Cardiovascular system / Public health systems and services research / Gene Targeting / Circulation / Embryos / ATRIUM / Vascular Endothelial Growth Factor / Mice / Female / Animals / Male / Heart / Fibroblast Growth Factor / Phenotype / Clinical Sciences / Eye / Cardiovascular system / Public health systems and services research / Gene Targeting / Circulation / Embryos / ATRIUM / Vascular Endothelial Growth Factor

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Enhanced vascular contractility in alpha1-adrenergic receptor-deficient mice

Life Sciences / Gene expression / Western blotting / Serotonin / Mice / Blood Pressure / Animals / Heart rate / Gene Targeting / Muscle contraction / Biochemistry and cell biology / Blood Pressure / Animals / Heart rate / Gene Targeting / Muscle contraction / Biochemistry and cell biology

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Chloroplast lysates support directed mutagenesis via modified DNA and chimeric RNA/DNA oligonucleotides

Plant Biology / DNA repair / Mutagenesis / Nucleic acid hybridization / Plant / Arabidopsis / Gene Targeting / Base Sequence / Chloroplasts / Arabidopsis / Gene Targeting / Base Sequence / Chloroplasts

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Use of an internal ribosome entry site for bicistronic expression of Cre recombinase or rtTA transactivator

Gene expression / Biological Sciences / Environmental Sciences / Mice / Animals / Nucleic Acids / Gene Targeting / Ribosomes / Protein Biosynthesis / Nucleic Acids / Gene Targeting / Ribosomes / Protein Biosynthesis

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EMILIN-1 Deficiency Induces Elastogenesis and Vascular Cell Defects

Cellular Biology / Electron Microscopy / Cell Adhesion / Extracellular Matrix / Biological Sciences / Cell morphology / Molecular and cellular biology / Humans / Mice / Female / Animals / Male / Heptad Repeat / Gene Targeting / Blood Vessels / Amino Acid Profile / SIGNAL PEPTIDE / Structural Similarity Index / Gene Family / Protein Binding / Molecular Interactions / Extracellular Matrix Proteins / Cell Adhesion Molecules / Elastic tissue / Cell morphology / Molecular and cellular biology / Humans / Mice / Female / Animals / Male / Heptad Repeat / Gene Targeting / Blood Vessels / Amino Acid Profile / SIGNAL PEPTIDE / Structural Similarity Index / Gene Family / Protein Binding / Molecular Interactions / Extracellular Matrix Proteins / Cell Adhesion Molecules / Elastic tissue

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Or83b Encodes a Broadly Expressed Odorant Receptor Essential for Drosophila Olfaction

Cognitive Science / Drosophila melanogaster / Signal Transduction / Phylogeny / Cell Differentiation / Odorant Receptor / Mutation / Animals / Smell / Central Nervous System / Dendrites / Egg Laying / Neuron / Fruit flies / Gene Targeting / Species Specificity / Olfactory Pathways / Neurosciences / Odorant Receptor / Mutation / Animals / Smell / Central Nervous System / Dendrites / Egg Laying / Neuron / Fruit flies / Gene Targeting / Species Specificity / Olfactory Pathways / Neurosciences

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Transgenic RNA interference in ES cell–derived embryos recapitulates a genetic null phenotype

Genetics / Stem Cells / Human Embryonic Stem Cells / RNA silencing / RNA polymerase / Multidisciplinary / Nature / Cell Division / Genetic Engineering / RNA interference / Cell line / Humans / Mice / Animals / Phenotype / Gene Function / Gene Targeting / Homologous Recombination / Embryos / ES cell / Multidisciplinary / Nature / Cell Division / Genetic Engineering / RNA interference / Cell line / Humans / Mice / Animals / Phenotype / Gene Function / Gene Targeting / Homologous Recombination / Embryos / ES cell

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Targeted Recruitment of Histone Acetyltransferase Activity to a Locus Control Region

Biological Chemistry / Biological Sciences / Humans / Mice / Animals / Histone Modification / Chromatin / CHEMICAL SCIENCES / Histones / Histone acetyltransferases / Gene Targeting / Transcription Start Site / Histone Modification / Chromatin / CHEMICAL SCIENCES / Histones / Histone acetyltransferases / Gene Targeting / Transcription Start Site

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Kaiso-Deficient Mice Show Resistance to Intestinal Cancer

Cellular Biology / Transcription Factors / Gene expression / Biological Sciences / Cell Differentiation / Molecular and cellular biology / Mice / Animals / Neurons / Phenotype / Colon cancer / Xenopus laevis / Gene Targeting / Molecular and cellular biology / Mice / Animals / Neurons / Phenotype / Colon cancer / Xenopus laevis / Gene Targeting

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Dendritic Targeting of mRNAs for Plasticity Genes in Experimental Models of Temporal Lobe Epilepsy

Animals / Male / Temporal Lobe Epilepsy / Neuronal Plasticity / Dendrites / Epilepsia / Clinical Sciences / Rats / Pilocarpine / Gene Targeting / Seizures / Protein isoforms / Subcellular Fractions / Reference Values / Neurosciences / Experimental Model / Epilepsia / Clinical Sciences / Rats / Pilocarpine / Gene Targeting / Seizures / Protein isoforms / Subcellular Fractions / Reference Values / Neurosciences / Experimental Model

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Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy

Multidisciplinary / Gene Silencing / Nature / Genetic Engineering / Gene Targeting / Transfection / Gene Expression Regulation / Transfection / Gene Expression Regulation

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